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October 2, 2023
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兩位科學家獲2023年諾貝爾生理學或醫學獎

瑞典卡羅琳醫學院 2日宣布,將2023年諾貝爾生理學或醫學獎授予科學家卡塔琳·考里科和德魯.韋斯曼,以表彰他們在信使核糖核酸(mRNA)研究上的突破性發現。

評獎委員會在當天發布的新聞公報中說,兩位獲獎者的研究成果「從根本上改變了對mRNA如何與免疫系統相互作用的理解」,對於在新冠疫情期間開發有效的mRNA疫苗至關重要。

在現代人類健康面臨威脅時,獲獎者的研究為疫苗前所未有的開發速度做出了重要貢獻。

兩位獲獎者研究發現,只要對細胞外生產的mRNA進行核苷酸鹼基修飾,就可以讓機體將外源mRNA「識別」為自身的mRNA,遞送後既能減少發炎反應又能增加蛋白質產量 , 這項成果消除了mRNA臨床應用道路上的關鍵障礙。

考里科1955年出生於匈牙利的索爾諾克,現任匈牙利塞格德大學教授和美國賓州大學佩雷爾曼醫學院兼職教授;韋斯曼1959年出生於美國麻薩諸塞州,現任賓州大學RNA創新研究所所長。

評獎委員會秘書托馬斯·佩爾曼在當天舉行的新聞發布會上表示,他已經與獲獎者們取得電話聯繫,考里科聽到消息感到不知所措,而韋斯曼表示很高興能獲獎。

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